14. The Big Bang Theory
Even though their characters Penny and Leonard are engaged on Big Bang, Kaley Cuoco-Sweeting and Johnny Galecki are no longer together after dating from 2008 to 2010. Cuoco-Sweeting has been married to Ryan Sweeting since 2013.
http://emertainmentmonthly.com/2014/11/09/big-bang-theory-reviewrecap-prom-equivalency/ Via EntertainmentMonthly
13. That 70s Couple
Mila Kunis and Ashton Kutcher met while playing Jackie Burkhart and Michael Kelso on That 70s Show. While their characters had an off-again, on-again relationship, Kunis and Kutcher did not get together off set until fairly recently. Rumors abound about whether they are married, but they did have their first child together in 2014.
http://www.huffingtonpost.com/2013/12/26/ashton-kutcher-mila-kunis-engagement-rumors_n_4503429.html Via HuffingtonPost
12. One Tree Hill
Chad Michael Murray (Lucas Scott) and Sophia Bush (Brooke Davis) could not make it work on and off the air. The couple was married for a few months before filing for divorce in 2006. Murray is now married to Sarah Roemer, who is currently pregnant with their first child.
http://www.celebuzz.com/?attachment_id=4809282 Via CeleBuzz.com
Love was lost between Dominic Monaghan (Charlie Pace) and Evangeline Lilly (Kate Austen) when the actors split in 2009 after dating for five years. Both would work together again in the Lord of the Rings trilogy as hobbit Meriadoc Brandybuck and elf Tauriel.
http://www.popsugar.com/celebrity/photo-gallery/30449911/image/30456367/Dominic-Monaghan-Evangeline-Lilly Via PopSugar.com