1. Clark Kent
   Stan Lee
2. Peter Parker
   James Howlett

Spider-Man is the alias of Peter Parker, a character created by Stan Lee and Steve Ditko. The well-known Marvel character made his first appearance in Amazing Fantasy #15 in August 1962.

1. Harry Osborn
   Ben Parker
2. Gwen Stacy
   Flash Thompson

Benjamin "Ben" Parker made his first appeared in Amazing Fantasy #15 (August 1962), a character created by Stan Lee and Steve Ditko. Uncle Ben is said to be modeled after American founding father, Benjamin Franklin.

1. Born that way
   Magic
2. Bitten by a radioactive spider
   An alien artifact

Peter Parker became Spider-Man after being bitten by a radioactive spider while at a science exhibit. Shortly after the bite, Peter developed superpowers like heightened strength, agility, and speed, just to name a few.

1. James Otto
   Alfred Molina
2. Tom Kenny
   Otto Octavius

Otto Octavius became Doctor Octopus after an accidental radiation leak caused the metal apparatus to fuse with his body. The well-known Spider-Man villain made his first appearance in The Amazing Spider-Man #3 in July of 1963.

1. Tom Holland
   Andrew Garfield
2. Tobey Maguire
   Mile Morales

Tobey Maguire is also well known for The Great Gatsby, Brothers, Seabiscuit, and Pleasantville.

1. Biff Tannen
   William Zabka
2. Flash Thompson
   Scut Farkus

Like Peter, Eugene "Flash" Thompson attended Midtown High School, where he bullied Peter on a daily basis. Flash has been portrayed in live-action movies by Joe Manganiello, Chris Zylka, and Tony Revolori.

1. Vulture
   Electro
2. Mysterio
   Doctor Octopus

Spider-Man went toe-to-toe with Adrian Toomes a.k.a. the Vulture (Michael Keaton) in Spider-Man: Homecoming. The iconic Spider-Man villain made his first appearance in The Amazing Spider-Man #2 in May of 1963.

1. Adrian Toomes
   Maxwell Dillon
2. Sergei Kravinoff
   Hobie Brown

Created by Stan Lee and Steve Ditko, Kraven the Hunter a.k.a. Sergei Kravinoff made his first appearance in The Amazing Spider-Man #15. Fun Fact: In In 2009, IGN's ranked Kraven 53rd on a list of the 100 Greatest Comic Book Villain of All Time.

1. Mr. Flanders
   Mr. Ditkovich
2. Mr. Kramer
   Mr. Osborn

Peter Parker's landlord Mr. Ditkovich, father of Ursula Ditkovich, was created exclusively for Sam Raimi’s Spider-Man and has never appeared in any movie or comic since. Mr. Ditkovich was portrayed by actor Elya Baskin.

1. Jimmy Olsen
   Pavitr Prabhakar
2. Miles Morales
   Benjamin Reilly

Also known as the Scarlet Spider, Benjamin Reilly was first introduced in The Amazing Spider-Man #149, during the “Clone Saga.” The Peter Parker clone was created by Gerry Conway.

1. Magician
   Special Effects/Stuntman
2. Doctor
   Cable Guy

Quentin Beck worked as a special effect and stuntman in the film industry before deciding to become the supervillain, Mysterio. The iconic Spider-Man villain made his first appearance in The Amazing Spider-Man #13 in June of 1964.

1. Peter Parker (Spider-Man Noir, Earth-912014)
   Miles Morales (Spider-Man, Earth-616)
2. Miguel O’Hara (Spider-Man 2099, Earth-928)
   William ‘Billy’ Braddock (Spider-UK, Earth-833)

In Spider-Man Noir, which takes place during the America's great depression of the 1930s, Peter Parker is a skilled marksmen known for using a revolver and sub-machine gun.

1. Orange
   Black
2. Blue
   Blonde

Created by Stan Lee and John Romita Sr., Mary Jane Watson’s red hair is synonymous with the character. MJ made a brief appearance in The Amazing Spider-Man #25 (1965), but her official reveal came in The Amazing Spider-Man #42 (1966).

1. Robert F. Simon
   Daran Norris
2. Ed Asner
   J.K. Simmons

J.K. Simmons returned to the role during the mid-credits scene of Spider-Man: Far From Home, marking the first time the silver-haired boss of The Daily Bugle has appeared in the MCU, although to keep up with the times, the Daily Bugle is now a web show.

1. The Bronx
   Queens
2. Brooklyn
   Staten Island

Following his parent's death, Peter Parker moves to a borough of Queens in New York City to live with his Aunt May and Uncle Ben. Parker makes reference Queens during Captain America: Winter Soldier (2014), when Cap says, "You got heart, kid. Where are you from?"

1. Aleksei Sytsevich
   Sergei Kravinoff
2. Maxwell Dillion
   Roderick Kingsley

Created by Stan Lee and Steve Ditko, Maxwell Dillion a.k.a. Electro made his debut in The Amazing Spider-Man #9 (1964). In 2014, the iconic villain was portrayed by Jamie Foxx in The Amazing Spider-Man 2.

1. Sally Field
   Rosemary Harris
2. Sissy Spacek
   Marisa Tomei

Marisa Tomei won an Academy Award in 1992 for her performance in My Cousin Vinny. Roughly 10 years later she was nominated once again for role In the Bedroom (2001) and again in 2008 for The Wrestler.

1. Cindy Moon
   May Parker
2. Julia Carpenter
   Jessica Drew

Jessica Drew made her first appearance in Marvel Spotlight #32 in winter of 1977 and two years later made his television debut in Spider-Woman. The animated television series ran for one season and aired from 1979 to 1980.

1. Miles Morales
   Miguel O’Hara
2. Ai Apaec
   Mac Gargan

While attempting to recreate Spider-Man’s abilities, Miguel O’Hara causes his DNA to be re-written with spider genetic code. The character was created by Peter David and Rick Leonardi in 1992.

1. Susan Storm/Invisible Woman
   Reed Richards/Mr. Fantastic
2. Ben Grimm/The Thing
   Johnny Storm/Human Torch

In Fantastic Four #587 (2011), Johnny Storm tragically passes away during battle with Annihilus' army. In homage to his longtime friend, Spider-Man accepts an invitation to join the Fantastic Four.

1. Mary Parker
   Jane Parker
2. May Parker
   Gwen Parker

Making her debut in What If? Vol 2 #105 back in February of 1998, May “Mayday” Parker is the daughter of Peter and Mary Jane. Created by Tom DeFalco and Ron Frenz, Mayday eventually became known as Spider-Girl.

1. Kingpin
   Tombstone
2. Green Goblin
   Mysterio

Quentin Beck a.k.a. Mysterio, made his first cinematic appearance in Spider-Man: Far From Home (2019). Other notable villains featured in Spider-Verse are Scorpion, Prowler, and Doctor Octopus.

1. Geoffrey Rush
   Willem Dafoe
2. Alfredo Molina
   Ben Kingsley

Since making his film debut in Indiana Jones and the Raiders of the Lost Ark in 1981, Molina has gone on to play roles in Frida (2002), Prick Up Your Ears (1987), Boogie Nights (1997), and Maverick (1994).

1. Nicholas Hammond
   David White
2. Paul Soles
   Mark Harmon

Nicholas Hammond played Peter Parker/Spider-Man in the live-action TV series 'The Amazing Spider-Man', which aired from 1977 to 1979. Hammond is also known for playing Friedrich von Trapp in the musical The Sound of Music (1965).

1. Tales to Astonish #34
   Amazing Fantasy #15
2. The Amazing Spider-Man #1
   Marvel Tales #7

Spider-Man made his debut in the final issue of the Amazing Fantasy comic book anthology series, which was in circulation from 1961 to 1962. The Amazing Fantasy name was been received since, but each time was short lived.

1. The Vulture
   J. Jonah Jameson
2. Nick Fury
   Talos

Adrian Toomes a.k.a. The Vulture, portrayed by Michael Keaton, was the main villain in Spider-Man: Homecoming (2017) and did not make an appearance in the sequel. The Vulture made his first appearance in The Amazing Spider-Man #2 (1963).

1. Felicia Hardy/ Black Cat
   Doreen Green/Squirrel Girl
2. Kitty Pryde
   Cindy Moon/Silk

Over the years, Peter Parker has dated Felicia Hardy, Cindy Moon, Kitty Pryde, Silver Sable, Rogue, Emma Frost, and many more, but Doreen Green a.k.a. Squirrel Girl is not one of them. Parker and Green most recently teamed up in The Unbeatable Squirrel Girl #28 (2015).

1. Man-Wolf
   Venom
2. Hobgoblin
   Lizard

John Jameson was created by Stan Lee and Steve Ditko, but it was Gerry Conway that turned Jameson into the werewolf known as Man-Wolf. He later became one of the lead characters in Creatures on the Loose.

1. Shameik Moore
   Brain Tyree Henry
2. Mahershala Ali
   Laurence Fishburne

Other than voicing Miles Morales' Uncle Aaron in the Oscar-winning Spider-Man: Into The Spider-Verse, Mahershala Ali is best known for roles in Luke Cage, Moonlight, Green Book, and Alita: Battle Angel.

1. The Chameleon
   Green Goblin
2. Venom
   Dr. Octopus

The Chameleon, also known as Dmitri Smerdyakov, was created by Stan Lee and Steve Ditko and made his first appearance in Amazing Spider-Man #1. He is also known as the half-brother of Kraven the Hunter.

1. A printing error.
   To avoid confusion with Superman.
2. It was actually Steve Ditko's idea.
   So fans didn't mistake the character for a Spider

During a conversation on Twitter back in February 2010, Stan Lee confirmed he hyphenated Spider-Man's name to distinguish the character from Superman, although many believe Marvel Comics was also concerned with infringing on DC Comics trademark.

1. John Romita Jr.
   Rob Liefeld
2. Stan Lee
   Brian Michael Bendis

John Romita Jr., son of iconic Spider-Man artist John Romita Sr., is best known for his work on various Marvel Comics titles from the 1970s to the 2010s. He is also known for illustrating the Kick-Ass comic book series.

1. Wesley Snipes as Blade
   Hugh Jackman as Wolverine
2. Patrick Stewart as Professor X
   Ben Affleck as Daredevil

Unable to get access to Wolverine's costume worn in X-Men (2000), Jackman's cameo was scrapped, despite the actor traveling to New York to shoot the scene. Wolverine and Spider-Man were never as close as Parker was with the Human Torch, but the pair have teamed up on various occasions.

1. Ultimate Spider-Man (2012)
   The Spectacular Spider-Man (2008)
2. Spider-Man: The New Animated Series (2003)
   Spider-Man: The Animated Series (1994)

Ultimate Spider-Man surpassed Spider-Man: The Animated Series during its third season, which was re-titled Ultimate Spider-Man: Web-Warriors. The show ran for four seasons and consists of 104 episodes.

1. Madeline Parker
   Anna Parker
2. Teresa Parker
   Mayday Parker

In that particular issue, Teresa Parker works for the C.I.A. and comes to Spider-Man's aid during a fight with a random gunman. Although fans were initially apprehensive upon hearing Peter Parker having a sister, Amazing Spider-Man: Family Business was generally been well-received.